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- The following questions are designed to solicit information critical to the State s evaluation of the offeror s capabilities in terms of the evaluation criteria identified in Section 4.1 of this RFP. Although the offeror s standard material may contain the requested information, the responses in this section will be an important critical component in the evaluation. In responding, offerors should repeat each question, followed by the answer. Answers should be concise, but complete. Offerors must respond specifically to each question in this section, regardless of whether the information appears in or may be gleaned from other sections of the offeror s proposal. Failure to respond in this section to all applicable questions may result in rejection of the offeror s proposal. To assist offerors in the preparation of their responses, a copy of this questionnaire is available as part of the RFP in WordPerfect 6.1 or Microsoft Word 97 format in either a disk format or by contacting the Department s Internet web site a t : dbm ate.md , select procurement.
Sent: saturday, november 05, 2005 7: subject: requip or mirapex for plms.
Sunita N. Chaudhari, MD Harold M. Glick, MD Leroy S. Indorato, MD Sheldon R. Levine, MD Jamie M. McNanie, MD Kim Ogle, MD Keith S. Somers, MD Childrens Community Pediatrics Healthquest Pediatrics 5321 William Flynn Hwy Gibsonia, PA 15044 724 ; 449-9300 Valentina E. Dicenzo, MD Ann S. Menzel, MD Caroline A. Sartschev, MD Heidi S. Swanson, MD Childrens Community Pediatrics Monroeville Peds Wb50 4075 Monroeville Blvd Ste 125 Monroeville, PA 15146 412 ; 373-1717 Carla T. Falcon, DO Elaine R. Joseph, MD Stewart G. Schott, MD William A. Varley, MD. Consider barbituate coma, general anesthesia, or diazepam drip. General Anesthesia- Will not stop the seizure activity within the brain but will stop the adverse effects of muscle convulsions including hyperthermia, rhabdomyolysis and acidosis. Following paralysis, the patient requires continuous EEG monitoring to determine status of seizure and methotrexate.Requip xk
ANTI-PARKINSON DRUGS PARKINSONS - ANTICHOLINERGICS AKINETON TABS BENZTROPINE MESYLATE TABS COGENTIN SOLN KEMADRIN TABS TRIHEXYPHENIDYL PARKINSONS - COMT INHIBITORS PARKINSONS - SELECTED DOPAMIN AGONISTS PARKINSONS DOPAMINERGICS CARBII LEVO COMTAN TABS 1 MIRAPEX TABS REQUIP TABS AMANTADINE HCL BROMOCRIPTINE MESYLATE CARBIDOPA LEVODOPA TABS * CARBIDOPA LEVODOPA ER LARODOPA TABS LODOSYN TABS SELEGILINE HCL APOKYN AZILECT2 ELDEPRYL CAPS PARLODEL CAPS PARLODEL TABS SINEMET TABS SINEMET TBCR SYMMETREL TABS ZELAPAR1, 2. Approvals will require trials of Carbidopa Levodopa, Selegiline, Comtan, and Stalevo. Use PA Form # 20420 PARKINSONS - COMBO. ALS DRUG MUSCLE RELAXANTS STALEVO MUSCLE RELAXANTS RILUTEK TABS BACLOFEN TABS CHLORZOXAZONE TABS CYCLOBENZAPRINE HCL TABS LIORESAL INTRATHECAL KIT METHOCARBAMOL TABS TIZANIDINE HCL TABS 7 8 MUSCLE RELAXANT COMBINATIONS ORPHENADRINE CITRATE CARISOPRODOL TABS DANTRIUM CAPS FLEXERIL TABS LIORESAL TABS NORFLEX TBCR ROBAXIN-750 TABS ZANAFLEX TABS SKELAXIN TABS SOMA TABS CARISOPRODOL ASPIRIN TABS CARISOPRODOL ASPIRIN CODE NORGESIC TABS ORPHENADRINE COMPOUND ORPHENADRINE ASA CAFF ORPHENGESIC VITAMINS VITAMINS * Preferred products that used to require diag codes still require diag codes unless indicated otherwise. * Use PA Form # 20420 ASCORBIC ACID TABS AQUASOL E SOLN BIOTIN CYANOCOBALAMIN SOLN FOLGARD RX 2.2 TABS FOLIC ACID TABS FOLTX TABS MEPHYTON TABS NIACIN AQUAVIT-E SOLN DHT SOLN NASCOBAL GEL Use PA Form # 20420 Non-preferred drugs will not be approved if members circumventing MaineCare prior authorization requirements by paying prescribers failed to submit prior authorization prior to cash narcotic scripts being filled by member ; . Non-preferred products must be used in specified step order. Use PA Form # 20420 1. Approvals will require concurrent therapy with Levodopa and failed trials of Selegiline, Comtan, and Stalevo. * Only preferred manufacturer's products will be available without prior authorization. TASMAR TABS Use PA Form # 20420 Use PA Form # 20420.Requip withdrawal
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Prescribed drugs and regulatory elements within promoters of transgene expression. Intracellular signaling after ligand-mediated activation of -adrenoceptors is mediated by intracellular adenosine-3 , 5 -cyclic monophosphate cAMP ; . Ligand-binding leads to the activation of adenylyl cyclase by G-proteins coupled to the cytosolic domain of the -adrenoceptor. Activation of adenylyl cyclase increases cAMP synthesis, which leads to activation by protein kinase A of the transcriptional factor cAMP-response element-binding protein CREB ; . The cAMP-response element CRE ; is an ubiquitous 8-base-pairlong palindromic DNA sequence that mediates the effects of cAMP on transcriptional activity.2 Once activated, CREB binds to CRE and stimulates assembly of the RNA polymerase complex which promotes transcription.2 The major immediate-early enhancer promoter from human cytomegalovirus MIEhCMV ; is a commonly used promoter of transgene expression, particularly in vascular gene therapy. In a recent review of experimental vascular and sustiva.
Systolic blood pressure was measured on conscious, restrained mice by use of the Visitech Visitech Systems ; tail-cuff system as described previously.28.Dosage of requip for rls
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Products and their versions may not be approved for all indications in all markets where they are available. Respiratory Seretide Advair, a combination of Serevent and Flixotide, offers a long-acting bronchodilator and an anti-inflammatory in a single inhaler. It is approved for the treatment of asthma and COPD. Flixotide Flovent and Becotide Beclovent are inhaled steroids for the treatment of inflammation associated with asthma and COPD. Serevent is a long-acting bronchodilator used to treat asthma and COPD, and Ventolin is a selective short-acting bronchodilator used to treat bronchospasm. Flixonase Flonase and Beconase are intra-nasal preparations for the treatment of perennial and seasonal rhinitis. Central nervous system CNS ; Seroxat Paxil is a selective serotonin re-uptake inhibitor SSRI ; for the treatment of depression, panic, obsessive compulsive disorder, post traumatic stress disorder, social anxiety disorder, premenstrual dysphoric disorder, and general anxiety disorder. Wellbutrin is an anti-depressant, available in the USA in normal, sustained-release SR ; and once daily formulations. Imigran Imitrex is a 5HT1 receptor agonist used for the treatment of severe or frequent migraine and cluster headache, and has become the reference product in this sector. Naramig Amerge is a newer migraine product. Lamictal, a well established treatment for epilepsy, is now also indicated for bipolar disorder. Requkp is a specific dopamine D2 D3 receptor agonist indicated for the treatment of Parkinson's disease and albendazole. If your prescription has been denied, you have the right to file an appeal to Express Scripts. The following section outlines your rights to file an appeal. 1. Adverse Determination means when the Plan determines that procedures performed or proposed to be performed are not medically necessary or are considered experimental or investigational and therefore are denied, reduced or terminated. An Adverse Determination does not mean a determination that the healthcare services are not covered. 2. Coverage Denial means services, treatments, drugs or devices that are specifically limited or excluded under the covered person's plan. 3. Administrative Appeals is for situations that do not fall in the category of either adverse determinations or coverage denials. For example, a member feels his her cost should be reduced from what is determined by the plan i.e., a drug is covered on the 3rd tier and the member feels the drug should be covered as a first or second tier co-pay.
This list is not all-inclusive. An application should not be submitted if a client is taking any of the following medications. 3TC Alkeran Amantadine Amiodarone Aricept Artane Avonex AZT Baclofen Betaseron Carbidopa Cogentin Cognex Copaxone Cordarone Cytoxan D4T DDC DDI DES Eldepryl Epogen Ergoloid Exelon Gold Haldol Herceptin Hydrea Hydergine Imuran Insulin 50 units day Interferon Indinavir Invirase Kemadrin Lasix 60 mg day L-Dopa Leukeran Levodopa Lioresal Lomustine AIDS Cancer Parkinson's Disease Heart Arrhythmia Dementia Dementia Multiple Sclerosis AIDS Multiple Sclerosis Multiple Sclerosis Parkinson's Disease Parkinson's Disease Dementia Mutliple Sclerosis Heart Arrhythmia Cancer, Severe Arthritis, Immunosuppression AIDS AIDS AIDS Cancer Parkinson's Disease Kidney Failure, AIDS Dementia Dementia Rheumatoid Arthritis Psychosis Cancer Cancer Dementia Immunosuppression, Severe Arthritis Diabetes AIDS, Cancer, Hepatitis, Multiple Sclerosis AIDS AIDS Parkinson's Disease Heart Disease Parkinson's Disease Cancer, Immunosuppression, Severe Arthritis Parkinson's Disease Multiple Sclerosis Cancer Megace Megestrol Mellaril Melphalan Memantine Methotrexate 20mg week Metrifonate Mirapex Myleran Namenda Narcotics Navane Nelfinavir Neoral Paraplatin Parlodel Permax Prednisone 10mg day Procrit Prolixin Remicade Reminyl Gequip Retrovir Rebif Riluzole Risperdal Ritonavir Sandimmune Sinemet Stelazine Symmetrel Teslac Thiotepa Thorazine VePesid Vincristine Viramune Zanosar Zoladex Cancer Cancer Psychosis Cancer Alzheimer's Disease Rheumatoid Arthritis Dementia Parkinson's Disease Cancer Alzheimer's Disease Chronic Pain Psychosis AIDS Immunosuppression, Severe Arthritis Cancer Parkinson's Disease Parkinson's Disease COPD, Rheumatoid Arthritis Kidney Failure, AIDS Psychosis Rheumatoid Arthritis, Crohn's Disease Dementia Parkinson's Disease AIDS Multiple Sclerosis ALS Psychosis AIDS Immunosuppression, Severe Arthritis Parkinson's Disease Psychosis Parkinson's Disease Cancer Cancer Psychosis Cancer Cancer AIDS Cancer Cancer and strattera!
Major haemorrhage in second or third trimester IMEESC Chapter 12 and WHO Pregnancy S-7 ; 1 ; Antepartum haemorrhage Placental abruption placental separation with blood loss concealed or revealed Placenta praevia placenta lies across the cervix Vasa praevia placental blood vessels lying in the membranes and in front of the baby's head. Uterine rupture usually related to a previous Caesarean Section or other operation on the uterus 2 ; Postpartum haemorrhage Uterine atony: The commonest cause Genital tract injury Retained products of conception. This is can be retained pieces, or the entire placenta. This is particularly likely if the placenta is excessively adherent as sometimes happens after a previous Caesarean Section 3 ; Coagulation Failure This may be due to a pre-existing coagulation problem, or in relation to complications of the pregnancy causing excessive bleeding and consumption of the clotting factors. Causes include: Placental separation before delivery Pre-eclampsia or eclampsia Retained dead fetus Septicaemia including intra-uterine sepsis Incompatible blood transfusion Amniotic fluid embolism Management of major haemorrhage in the second or third trimester. They started him on requip and that did nothing, then a second medicine that slips my mind and also nothing and indinavir.
Providing the Alzheimer patient with nutritious meals and snacks is a problem for many caregivers. Often the patient can't sense or identify hunger or fullness, or the need for fluids or foods with certain vitamins and minerals. Predictability The resident's response to food is also difficult to predict. An individual might like specific foods such as turkey or chicken and then--without warning--turn away from these foods. Poor Nutrition The result of poor nutrition among Alzheimer patients is usually weight loss or gain and a variety of other symptoms, including poor-fitting dentures, listlessness, and fatigue. A resident who snacks regularly on such foods as candy and pastries often experiences a "sugar high" followed by complaints of being tired, depressed, or hungry. "Junk foods" tend to make the resident more restless and disoriented, and reduce the craving for regular meals and more nutritious foods. The resident may also experience bowel or bladder problems because of not drinking enough fluids or eating adequate fiber. Disease Progression As the disease progresses, providing the resident with proper nutrition may become even more difficult. The individual might not understand the timing of meals or the difference between breakfast, lunch, dinner and snacks. In addition, you may have to offer more coaching at mealtime to help the resident use utensils, for chewing, swallowing, or identifying various foods. For example, you may hand the resident a spoon only to discover that he or she can't remember how to use it. In another situation, a resident who feels no need for food may clench their jaw tightly and refuse to let you put a utensil near their mouth. This resident may not understand or remember what to do with food. Sent: wednesday, october 30, 2002 2: subject: requip to permax i've been on requip for a year and aricept. Problems with meds so far: requip & mirapex & ultram: cause insomnia, neurontin: dizziness thanks for your generous work in this sleepless world.Requip online
Sent: wednesday, january 25, 2006 7: subject: my rls i wrote to you a couple of years ago, and you expressed concern that my dosage of 6 mg requip per day was hefty. Ropinirole requip ; , pergolide permax ; , and pramipexole mirapex ; cause fewer side effects compared with levodopa and have become first-line drugs in the treatment of restless legs syndrome and periodic limb movement disorder and antabuse and Buy requip online. Crystal Structures of Alpha-11 Giardin nates restrained by non-crystallographic symmetry NCS ; in CNS. Four calcium ions and ordered solvent water molecules were added using water pick in CNS and by visual inspection. Several rounds of re-building were continued based on 3Fo2Fc, 2FoFc, FoFc, NCS-averaged and 2FoFc simulated annealing omit maps, and subsequent rounds of refinement were carried out with the program CNS using data to the maximum resolution of 2.93 . The final model of apo alpha-11 giardin includes one monomer per asymmetric unit residues 2305 ; , 620 water molecules and two sulfate ions. The final model of Ca2 + bound alpha-11 giardin includes four monomers, 111 water molecules and four calcium ions. Good stereochemistry for the apo alpha-11 giardin and Ca2 + -bound alpha-11 giardin models was confirmed using the program PROCHECK.44 Final refinement statistics for apo alpha11 giardin and Ca2 + bound alpha-11 giardin are listed in Table 2. Vesicle pull-down assay Phospholipid vesicles composed of POPS ; and POPC ; were prepared in a 1: molar ratio.24 25 mg of POPS and 97.1 mg of POPC Avanti Polar Lipids ; were dissolved in 4 ml of chloroform and 2 ml of methanol. The organic solvents were evaporated under a stream of nitrogen and dried overnight. The lipids were dissolved in phospholipid buffer 50 mM imidazoleHCl pH 7.4 ; and 100 mM NaCl ; and then subjected to four freeze-thaw cycles. Small unilamellar vesicles 0.2 m in size were prepared by filtering through an extruder 15 times ; at 37 C. The association of alpha-11 giardin with the vesicles was assessed with a co-pelleting assay using annexin A2 as a positive control and ovalbumin as a negative control.19 For each reaction 200 l ; , a total of 20 nmol of vesicles were incubated with 0.2 nmol of protein in phospholipid buffer with varying amounts of calcium chloride 0.05 mM10 mM ; . All samples were incubated for 1 h at room temperature and then centrifuged for 10 min at 14, 000g to separate vesicles with protein bound pellet ; from soluble protein supernatant ; . Pellet and supernatant samples were analyzed on an SDSPAGE gel and subsequently stained with Coomassie brilliant blue results not shown ; . Protein Data Bank accession codes The atomic coordinates and structure factors for apo and Ca2 + -bound alpha-11 giardin have been deposited in the RCSB Protein Data Bank under the accession codes 2II2 and 2IIC, respectively. Dermatomyositis This is a disorder involving skin and skeletal muscle. In adults it is associated with internal malignancy in 50% of cases. All cases should be assessed as temporarily unfit and referred to the AMS. The prognosis is variable and [a fit assessment] may be considered where appropriate and lariam.
15. Allow an equilibration period of 45 min, during which time blood gases and temperature will stabilize. Towards the end of this period, take an arterial blood sample for blood gas analysis using a Radiometer ABL500 blood-gas analyzer. Adjust respiration if necessary to give a blood pO2 between 90 and 110 mmHg, pCO2 between 35 and 45 mmHg, and a pH between 7.35 and 7.45, when the body temperature is between 36 and 37.5C.
Pharmaceutical companies to identify other published and unpublished studies. Their search identified 22 randomized trials; 10 compared lactulose or lactitol with placebo or no intervention, and 12 compared them with antibiotic therapy. While the results against placebo or no treatment were favorable when all evaluated studies were considered, there was no benefit when only the high-quality studies were compared Figure 2 ; .14 The results of the comparison of the nonabsorbable disaccharides and antibiotic therapy favored the use of the antibiotics over the nonabsorbable disaccharides Figure 3 ; .14 No difference was found between the potential efficacy of lactulose or lactitol on mortality and risk of no improvement; the authors noted that this evaluation was underpowered for the purpose of establishing whether these treatments had comparable effects. In addition, the nonabsorbable disaccharide therapy appears to be inferior to antibiotic therapy in reducing the risk of no improvement. The investigators concluded that there is insufficient high-quality evidence to determine if nonabsorbable disaccharides are beneficial in the treatment of hepatic encephalopathy; antibiotics appear to be better than nonabsorbable disaccharides in improving the symptoms of hepatic encephalopathy, but whether these differences are clinically important remains to be proven; and nonabsorbable disaccharides should not be used as the comparator in randomized trials evaluating the efficacy of any new hepatic encephalopathy treatment modalities.14, 15 Flatulence, abdominal discomfort, and diarrhea are common adverse effects associated with nonabsorbable disaccharides. Diarrhea sufficient to cause dehydration and electrolyte imbalances in some patients could worsen the encephalopathy. If the latter occurs, the dose of the nonabsorbable disaccharide should be decreased, if possible, or discontinued and antibiotic therapy initiated.1, 17.
It must state unequivocally that it wants to create a health care market involving a range of different providers and that it believes this model represents the long-term future for the health service in England. : kingsfund resources publications designing the Department of Health NHS inpatient and outpatient waiting times April 2006 : dh.gov assetRoot 04 13 56 NHS Institute for Innovation and Improvement - Delivering quality and value: focus on productivity and efficiency This report details savings that could be made by addressing areas such as: Reducing avoidable emergency admissions Increasing the number of operations carried out as daycases Cutting length of stay in hospital Slashing agency staff costs Reducing the number of wasted bed days : institute.nhs Products ProductivityandEfficiency National Audit Office Efficiency Toolkit This provides practical guidance on assessing an organisation's current approach to achieving efficiency. : nao efficiency toolkit index Department of Health National framework for NHS funded healthcare and NHS funded nursing care in England: a consultation This national framework has two main purposes: It sets out a single policy on who should receive NHS funding It proposes a standard process for assessing eligibility for these services, to help support consistent decision making The deadline for responses to the consultation is 22 September 2006. : dh.gov Consultations LiveConsultations LiveConsultationsArticle fs e n?CONTENT ID 4136175&chk fOAfTD NHS Confederation Inspectors and regulators of health services This briefing explains the roles of the various inspectors and regulators of the NHS and the ways in which they are changing. It explains the differences and the relationship between regulation and inspection, and how NHS organisations need to be ready to deal with their demands. : nhsconfed docs inspectors STAFFING ISSUES The Information Centre NHS Sickness Absence The national sickness absence level for 2005 is 4.5%. This rate compares with 4.6% for 2004 and 4.7% for 2003. The rates of sickness vary considerably by trust type. Sickness absence is considerably higher in ambulance trusts 6.0% ; than in acute trusts 4.4% ; . : ic.nhs pubs sicknessabsencerates. The Debtor testified that she also has two topical ointments for the acne, which she tries to stretch for two months at a time. She also testified that she has been prescribed an anti-depressant that she does not take because "it's the only one I can live without, and it's too expensive." DEBTOR' S TEST. at 28. The total cost of the Debtor's prescribed medications is 5.00 per month. Please reply thanks posted by wayne at mon 6 jun 2005, in comtan 1 reply no subject c200 helps along with the requip 3 day ; and c l 25 250 it seems that i cant go beyond three hrs and buy sustiva.Under a wide range of assumptions, ropinirole ReQuip ; appears to generate cost offsets that exceed the additional drug cost of therapy for this innovative drug. Loss of productivity is the major factor offsetting the drug cost, followed by caregiver-associated costs. Adoption of this new drug would be beneficial for society.
Other events reported by 1% or more of patients treated with both REQUIP and L-dopa, but equally or more frequent in the placebo L-dopa group, were: myocardial infarction, orthostatic symptoms, virus infections, asthenia, dyspepsia, myalgia, back pain, depression, leg cramps, fatigue, rhinitis, chest pain, hematuria, vertigo, tinnitus, leg edema, hot flushes, abnormal gait, hyperkinesia, and pharyngitis. Among the treatment-emergent adverse events in patients treated with REQUIP, hallucinations and dyskinesias appear to be dose-related. Restless Legs Syndrome: The most commonly observed adverse events 5% ; in the 12-week double-blind, placebo-controlled trials in the treatment of Restless Legs Syndrome with REQUIP n 496 ; and at least twice the rate for placebo-treated patients n 500 ; were, in order of decreasing incidence: nausea, somnolence, vomiting, dizziness, and fatigue see Table 4 ; . Occurrences of nausea in clinical trials were generally mild to moderate in intensity see also DOSAGE AND ADMINISTRATION: General Dosing Considerations ; . Approximately 5% of 496 patients treated with REQUIP who participated in the double-blind, placebo-controlled trials in the treatment of RLS discontinued treatment due to adverse events compared to 4% of 500 patients who received placebo. The adverse events most commonly causing discontinuation of treatment by patients treated with REQUIP were: nausea 1.6% ; , dizziness 0.8 % ; , and headache 0.8% ; . Adverse Event Incidence in Controlled Clinical Studies: Table 4 lists treatment-emergent adverse events that occurred in 2% of patients with RLS treated with REQUIP participating in the 12-week double-blind, placebo-controlled studies and were numerically more common in the group treated with REQUIP. The prescriber should be aware that these figures cannot be used to predict the incidence of adverse events in the course of usual medical practice where patient characteristics and other factors differ from those that prevailed in the clinical studies. Similarly, the cited frequencies cannot be compared with figures obtained from other clinical investigations involving different treatments, uses, and investigators. However, the cited figures do provide the prescribing physician with some basis for estimating the relative contribution of drug and non-drug factors to the adverse-events incidence rate in the population studied. Parkinson's Medications Length of Authorization: 1 year Key: Generic product, * Indicates generic equivalent is available without a PA PREFERRED DRUGS No PA Required ; PA REQUIRED DOPAMINE PRECURSOR Sinemet * CARBIDOPA LEVODOPA compare to Sinemet ; * CARBIDOPA LEVODOPA ER compare to Sinemet CR ; Sinemet CR PARCOPA carbidopa levodopa ODT ; DOPAMINE AGONISTS ORAL ; Parlodel * bromocriptine ; BROMOCRIPTINE compare to Parlodel ; MIRAPEX pramipexole ; REQUIP ropinirole ; DOPAMINE AGONISTS TOPICAL ; Neupro Patch rotigotine transdermal ; QL 1 patch day ; COMT INHIBITORS TASMAR tolcapone ; COMTAN entacapone ; MAO-B INHIBITORS Eldepryl * selegiline ; SELEGILINE compare to Eldepryl ; Azilect rasagiline ; QL 1 mg day ; Zelapar selegiline ODT ; QL 2.5 mg day ; OTHER Symmetrel * amantadine ; AMANTADINE compare to Symmetrel ; STALEVO carbidopa levodopa entacapone. When can you get requip in generic form.
C: Abstracts Atchley, DPD, and Eckel, LA. 2005 ; . C-Fos expression in response to fenfluramine in rats with activity-based anorexia. Soc. Neuro. Abstr, 30, Program No. 874.12, Washington, D.C. Atchley, DPD, and Eckel LA. 2005 ; . 8-OHDPAT attenuates development of activity-based anorexia. Appetite Abstr, 44: 331. Soc. Study of Ingestive Behav., Pittsburgh, PA. Dixon, DP, and Eckel LA. 2004 ; . Fenfluramine-induced changes in taste responses to sucrose solutions in cycling female rats. Soc. Neuro. Abstr. 29, Program No. 763.19, San Diego, CA. Dixon, DP, Rivera, HM, and Eckel, LA. 2004 ; . Estrous-related changes in ingestive and locomotor activity in relation to changes in vaginal cytology across the rat's 4-day estrous cycle. Appetite Abstr. 42: 356. Soc. Study of Ingestive Behav., Cincinnati, OH. Dixon, DP, and Eckel, LA. 2003 ; . Rats that have recovered from activity-based anorexia can regulate their body weight when re-exposed to a restricted-feeding schedule. Appetite Abstr.40: 15. Soc. Study of Ingestive Behav., Groningen, Netherlands. Dixon, DP, Rivera, HM, Moore, SR, Duke, KC, and Eckel, LA. 2003 ; . Time course of vaginal cytology as a predictor of estrous stage and behavioral estrous. Soc. Neuro. Abstr. 28, Program No. 83.8, New Orleans, LA. Rivera, HM, Dixon, DP, and Eckel, LA. 2003 ; . Fenfluramine-induced hypophagia, but not hypoactivity, is sexually dimorphic. Appetite Abstr 40: 43. Soc. Study of Ingestive Behav., Groningen, Netherlands. Dixon, DP, and Eckel, LA. 2002 ; . Food-restriction induced hyperphagia is modulated by the estrous cycle. Horm. Behav. Abstr., 41: 464. Soc. Behav. Neuroendocrin., Amherst, MA. Dixon, DP and Eckel, LA. 2002 ; . Fenfluramine enhances activity-based anorexia in female rats. Appetite Abstr., 39: 73. Soc. Study of Ingestive Behav., Santa Cruz, CA. Dixon, DP, Rivera, HM, and Eckel, LA. 2002 ; . Fenfluramine-induced hypophagia is increased during estrus in female rats. Appetite Abstr., 39: 73. Soc. Study of Ingestive Behav., Santa Cruz, CA. Dixon, DP, and Eckel, LA. 2002 ; . Activity-based anorexia in female rats is influenced by changes in serotonergic activity. Soc. Neuro. Abstr.27, Program No. 869.8., Orlando, FL. * This abstract was also selected to be in the SFN 2002 press book. In December our US marketing partner Endo Pharmaceuticals launched DepoDurTM, our new injectable analgesic for the treatment of pain after surgery. Sales in the first half of 2005 were .3 million. Given the length of time typically needed to establish hospital products, we are confident that this initial sales level does not reflect the full potential of the product. In the UK, we were informed by the UK regulatory agency, the CSM, that it will recommend approval for DepoDurTM, subject to certain conditions being satisfied. We are in discussions with the CSM about these conditions which do not require further clinical trials ; . Assuming final approval is received, the UK approval will be used as the basis for seeking approval throughout the European Union under the EU's Mutual Recognition procedure. DepoDurTM will be marketed in Europe by our partner Zeneus Pharma. Following FDA approval in May, First Horizon Pharmaceutical Corporation launched TriglideTM fenofibrate ; on the US market in July. We licensed TriglideTM, an oral treatment for elevated blood lipid disorders, to First Horizon in 2004. We will receive 25% of First Horizon's net sales of this product in the form of royalty income and manufacturing revenues. More details on TriglideTM will be found in the feature on page 3. Products in late-stage development Foradil Certihaler is our new version of Novartis' long-acting bronchodilator Foradil formoterol ; . We developed not only the multidose dry-powder inhaler device but also the formulation technologies that ensure dose consistency regardless of storage conditions. These technologies are also involved in a new collaboration with Novartis to jointly develop another bronchodilator, QAB149. The product has now been launched in Germany and is approved in eleven other countries in Europe, Latin America and South Africa. In the USA, where the product will be marketed by ScheringPlough, Novartis has responded to the FDA about the conditions imposed in a second "approvable" letter issued in December 2004. We have completed Phase III trials of Gequip CRTM, the once daily version of GlaxoSmithKline's Parkinson's drug Requip. The product is expected to be filed by GlaxoSmithKline later this year.
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