Academic dissertation to be publicly discussed, with the assent of the medical faculty of the university of helsinki, in the psychiatric centre auditorium christian sibelius, vlskrinkatu 12, on june 16, 2006, at 12 noon.
Flood the market causing prices for the drug to plunge. Forest's business strategy was to work with its licensor Lundbeck to develop a follow-on patented drug Lezapro which contained the same active ingredient as Celexa and therefore would be essentially the same as Celexa, but with sufficient claimed differences to justify the follow-on drug being granted a patent and its own period of marketing exclusivity extending for several years beyond Celexa "going generic, " and to allow Forest to credibly claim the new Lexarpo drug was superior in treating depression so as to justify physicians continuing to prescribe it to patients at much higher prices compared to generic Celexa. Once Lexapr was approved for sale by the FDA, Forest would stop.
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Acute admission wards serve people experiencing a wide variety of mental health problems as well as bipolar disorder and often have to manage high levels of distress, need and disturbance. Admission should provide safety for actively suicidal, behaviourally disturbed or vulnerable individuals. Admission to hospital can also offer a valuable opportunity for systematic and collaborative multidisciplinary assessment and care-planning, as well as an opportunity for the expert review of pharmacological and other treatments. All inpatient units should seek to provide a safe, culturally competent and supportive environment. This environment should offer patients a structured day, incorporating groups and activities which seek to reduce distress and enhance coping skills as well as also providing appropriate opportunities for recreation and relaxation. Ward programmes, or programmes accessible to inpatients, should incorporate psychoeducation; techniques for enhancing coping strategies, managing anxiety, anger and self-harm; techniques for coping with specific symptoms such as hearing voices and managing medication; as well as other opportunities to engage in other structured activities. Additional to such programmes it is also essential that all inpatients receive regular individual attention from staff. These one-to-one sessions should incorporate a focus on techniques for managing distress, assisting the patient to envisage and work towards achieving solutions to their current problems and to enhancing their coping strategies, as well as providing ongoing psychological support. Effective inpatient care should also embrace the patient's family, carers and friends and ensure that both the patient and the inpatient care team remain in close contact with other professionals and agencies involved in his her ongoing care. Patients with bipolar depression may experience a wide-range of problems including profound anergia, psychomotor retardation, marked social withdrawal and selfneglect. These patients need regular skilled nursing input at a number of different levels. At the most basic level, the fluid balance of patients with profound depression may need to be monitored and considerable nursing time and input may be necessary to ensure that they maintain an adequate intake of food and fluids. While depressed, these patients may need time, assistance and gentle support and encouragement to maintain their basic hygiene and self-care. These patients should receive regular oneto-one attention from staff who should employ techniques such as activity scheduling to help them structure their day and gradually increase their activity levels. Staff 140.
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FDA ; for the treatment of major depressive disorder. Forest expects Lexapto to be available in pharmacies by September 5th. 11. On 9 5 02, Kenneth Goodman, Forest's President and Chief Operating Officer.
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Lexapro and Effexor XR require step therapy with at least one of the following generic formulary alternatives; Prozac [g], Paxil [g], Celexa [g], Luvox [g], Wellbutrin SR [g], Wellbutrin XL [g], Remeron [g], Effexor [g] or Zoloft [g]. Pristiq: requires trial failure of at least 2 formulary agents. Luvox CR; requires trial failure of at least 2 formulary agents plus documentation that continued use of Luvox [g] will adversely affect the member's mental health. Paxil CR Pexeva; requires trial failure of at least two of the above formulary agents PLUS documentation that continued use of Paxil [g] will adversely affect the member's health. Prozac Weekly; requires trial failure of at least two of the above formulary agents PLUS documentation that continued use of Prozac [g] will adversely affect the member's health and clozaril.
Need 5 lingas straight branch with leave and shoot ; of each species of Sal, Bamboo and Banana Leave of Pipal, Bar and Bel Rope of Babiyo Different fruits Need a piece of wood especially Sal Bamboo pieces Leave of Sal Banana's leave Need leave of Usir, Bhringiraj Bhringijar, Bhangarai and Apamarga Used a linga close to cementry it means the dead body can not cross over the shade of linga? ; Branch of Asuro with leave and shoot and put on trail Children follow his her parents or relatives when s he leave the home for long time so s he break the branch and keep the shoot portion of branch towards house on trail. It is doing because the child children will not sick or Sato ajaos ; . Leave of Pipal, Bar, Mango, Sal, Bhalayo, Spike of Nibua Flower of various plants according to season Need 5 Lingas of Sal, Bamboo and Banana Leave of Mango, Kush, Dubo, Rope of Babiyo Stick of Painyu Various flowers and Jauteel Homan samida of Khayar or Sal Homan samida of Khayar or Sal Various flowers Bamboo Khocha made from the leave of Sami or Kavro or Dumri and put into river Kholama Bagaune ; Need of Kurilo plant, Kukurddaaino, Siru, Bhalayo, Khirro Four piece of fuelwood with fire Agulta ; for throwing in four direction Need of Datiwan Various flowers including new yellow maize plant A plant of Sugarcane Khocha made from leave of Nibuwa or Dhursyauli for lamp Various flowers including Titepati Rope of Babiyo Various flowers Prasad of different fruits, cereal and milk of cow Need 5 linga of Sal, Bamboo and Banana Various fruits and flowers Coconut with coverage Jata sahit ko ; Oil of Teel Prasad of different fruits, cereal and milk of cow A kind of sweet Laddu ; of Teel Similar to Brahmin Chhetri.
Antianxieties physically psychologically addictive negative reinforcement valium, xanax, librium, atavan used to be the most prescribed drugs antidepressants pre-1988: maoi tricyclics; neurogenesis sprouting new dendrites prozac used to be very strong when it didnt need to be post-1988: ssris block reabsorption of serotonin ; paxil, zoloft, celexa, lexapro 80% benefit reports; takes up to 6-weeks to feel effects wellbutrin blocks reabsorption of serotonin, norepinephrine, and dopamine and zoloft.
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At this time, it may be a good idea to reduce the lexapro dosage by a quarter or so!
2 "We are pleased that ABILIFY aripiprazole ; has achieved this important milestone as the first medication approved as adjunctive treatment for adults with major depressive disorder, " said Taro Iwamoto, Ph.D., Chief Executive Officer, President and Chief Operating Officer, Otsuka Pharmaceutical Development and Commercialization, Inc. "This new add-on treatment option for depression represents hope for many adults suffering from this debilitating illness." Major depressive disorder affects millions of U.S. adults at some point in their lives.2 A recent study evaluated different treatment approaches, including adjunctive medications and switching strategies, in patients with MDD.1 The study found that 63% of patients did not achieve adequate relief of depressive symptoms following the initial treatment with an antidepressant alone.1 Additionally, the study demonstrated that the use of adjunctive medications in treatment may be useful to improve unresolved depressive symptoms.1 Clinical Trial Design and Findings Two six-week, double-blind, randomized, placebo-controlled, multicenter studies evaluated the efficacy and safety of add-on ABILIFY in adult patients with a primary diagnosis of major depressive disorder who had experienced an inadequate response to prior antidepressant therapy one to three courses ; in the current episode. After an eight-week prospective treatment phase with one ADT plus single-blind placebo to confirm inadequate response to ADT, 743 participants entered a six-week randomized treatment phase during which they continued their ADT plus double-blind adjunctive placebo or adjunctive ABILIFY. All study participants received one of the commonly prescribed ADTs, including selective serotonin reuptake inhibitors SSRIs ; : Lexapro escitalopram ; , Prozac fluoxetine ; , Paxil CR paroxetine controlled-release ; , Zoloft sertraline or a serotonin-norepinephrine reuptake inhibitor SNRI ; : Effexor XR venlafaxine extended release ; . The dosage range for adjunctive ABILIFY was 2-20 mg day 15 mg day was the maximum dose for patients receiving ABILIFY as an adjunct to Paxil CR or Prozac ; . The primary efficacy endpoint was the mean change from baseline the end of the prospective treatment phase to the end of the randomized treatment phase in a standard measure called Montgomery-Asberg Depression Rating Scale MADRS ; , a 10-item clinician-rated scale used to assess depressive symptoms. A reduction in MADRS Total Score represents an improvement in depressive symptoms. The key secondary endpoint was the Sheehan Disability Scale SDS ; , a three-item self-rated instrument used to assess the impact of depression on three domains of functioning work school, social life and family life ; with each item scored from zero and compazine.
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Tell your doctor if you take $ propranolol $ selective serotonin reuptake inhibitors SSRIs ; or serotonin norepinephrine reuptake inhibitors SNRIs ; , two types of drugs for depression or other disorders. Common SSRIs are CELEXA citalopram HBr ; , LEXAPRO escitalopram oxalate ; , PAXIL paroxetine ; , PROZAC SARAFEM fluoxetine ; , SYMBYAX olanzapine fluoxetine ; , ZOLOFT sertraline ; , and fluvoxamine. Common SNRIs are CYMBALTA duloxetine ; and EFFEXOR venlafaxine ; . These medicines may affect how FROVA works, or FROVA may affect how these medicines work. How should you take FROVA? Take one FROVA tablet anytime after the start of your migraine headache. If your headache comes back after your first dose, you may take a second tablet after two 2 ; hours. Do not take more than three 3 ; FROVA tablets in a 24-hour period. If you take too much medicine, contact your doctor, hospital emergency department, or poison control center right away. What are the common side effects of FROVA? The most common side effects associated with use of FROVA are: $ dizziness $ fatigue tiredness ; $ headache other than a migraine headache ; $ paresthesia feeling of tingling ; $ dry mouth $ flushing hot flashes ; $ feeling hot or cold $ chest pain $ dyspepsia indigestion ; $ skeletal pain pain in joints or bones.
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The first generic version of Lexapro, one of the most widely prescribed antidepressants, with more than billion in sales last year, received federal approval. FDA officials approved 5, 10 and 20 milligram doses of the drug, also called escitalopram oxalate, for the treatment of major depression. In 2005, Lexapro was the No. 2 antidepressant in the U.S., behind Zoloft, with 29.6 million prescriptions filled, according to IMS Health, a prescription information provider. Lexapro's U.S. sales last year were .1 billion and amitriptyline.
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Analyzed the association between dandelion ITS sequence polymorphism, agamospermy, polyploidy, hybridization, and the phylogenetic information. Up to now, phylogenetic analysis of Taraxacum was limited to the study of plastome, a method able to reveal major trends in the evolution of cpDNA, but not fully appropriate to identify pathways of multiple reticulation events due to uniparental inheritance and relatively low level of phylogenetically relevant variation within the Taraxacum cpDNA. Our project is aimed at tracing parental genomes of polyploid hybridogenous dandelions in order to reconstruct the complicated reticulation history. As a material, we selected polyploid tri- and tetraploid ; agamosperms of the Taraxacum sections Leucantha, Stenoloba and Suavia, and compared them with related or similar sexuals, usually diploids. We selected nrDNA ITS regions, and expected that, under the condition of suppressed concerted evolution, the variation would represent a thesaurus of parental sequences, together with results of the later mutation process. Internal transcribed spacers ITS1 and ITS2 ; of nuclear ribosomal DNA nrDNA ; of 31 species of three C Asian sections of Taraxacum were sequenced. Individual plants of Taraxacum taxa contain polymorphic nucleotide sites in the ITS1 and ITS2 regions. To characterize the intragenomic variation, we sequenced 10 clones from each individual. These sequences show polymorphism among clones. This polymorphism supports the hypothesis of the suppressed ITS homogenization in agamospermous polyploid dandelions. Moreover, the preliminary results show that the interclonal variation involves minor variants very close to one another, and a group of major variants, occupying very remote branches of the cladogram. To sum up, the main goals of this work were 1 ; to test a hypothesis that a comparison of ITS clones is a suitable tool for phylogenetic reconstruction of the reticulation in Taraxacum, and 2 ; to reveal probable evolutionary relationships among selected hybridogenous apomicts in C Asia. What remains is a comparison with the most important related groups of dandelions, including the diploid sexuals, probably close to the parental taxa of C. Asiatic dandelions. Phylogeny and evolution of spider parasitoids within Pimplinae Hymenoptera, Ichneumonidae ; . Jacques Dubois * and Ian D. Gauld. FRE 2695 CNRS, Depart ement Systematique et Evolution, Museum National d'Histoire Naturelle, 45, rue Buffon, 75005 Paris, France; The Natural History Museum, Entomology, Cromwell Road, London, UK The subfamily Pimplinae displays the most diversified patterns of parasitism within the Ichneumonidae. They are associated with a wider host range than in any other subfamily of Ichneumonidae, and species are known to parasitize many groups of a phytophagous or xylopha and abilify.
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THIS DECISION HAS BEEN APPEALED. THE FOLLOWING IS THE RELATED SOAH DECISION NUMBER: SOAH DOCKET NO. 453-05-0541.M5 MDR Tracking Number: M5-04-3431-01 Under the provisions of Section 413.031 of the Texas Workers' Compensation Act, Title 5, Subtitle A of the Texas Labor Code, effective June 17, 2001 and Commission Rule 133.305 titled Medical Dispute Resolution - General and 133.308 titled Medical Dispute Resolution by Independent Review Organizations, the Medical Review Division Division ; assigned an IRO to conduct a review of the disputed medical necessity issues between the requestor and the respondent. The dispute was received on 06-08-04. The Division has reviewed the enclosed IRO decision and determined that the requestor did not prevail on the majority of the medical necessity issues. Therefore, the requestor is not entitled to reimbursement of the IRO fee. Based on review of the disputed issues within the request, the Medical Review Division has determined that medical necessity was the only issue to be resolved. The Vioxx, Hydrocodone APAP, Lexapro and Promethazine were found to be medically necessary. The Carisoprodol and Amerge were not found to be medically necessary. The respondent raised no other reasons for denying reimbursement for Vioxx, Carisoprodol, Hydrocodone APAP, Lexapro and Amerge. On this basis, and pursuant to 402.042, 413.016, 413.031, and 413.019 of the Act, the Medical Review Division hereby ORDERS the respondent to pay the unpaid medical fees in accordance with the fair and reasonable rate as set forth in Commission Rule 133.1 a ; 8 ; plus all accrued interest due at the time of payment to the requestor within 20-days of receipt of this Order. This Order is applicable to dates of service 06-10-03 through 07-07-03 in this dispute. The respondent is prohibited from asserting additional denial reasons relative to this Decision upon issuing payment to the requestor in accordance with this Order Rule 133.307 j ; 2 and anafranil.
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Diversity: Current Perspectives and potential applications held at University of Delhi south Campus, New Delhi from April 16-18, 2005. 50. Maqbool, Q. A., Johri, S., Riyaz-ul-Hassan, S., Rasool, S., Koul, S., Taneja, S.C., Verma, V. and Qazi, G. N. 2005 ; Molecular cloning of an enantioselective carboxylesterase from Bacillus subtilis RRL BB1. Proceedings of International Conference on Microbial Diversity: Current Perspectives and potential applications held at University of Delhi south Campus, New Delhi from April 16-18, 2005. 51. Vakhlu, J., Johri, S., Verma, V., Koul, S., Parshad, R., Taneja, S. C. and Qazi, G. N. 2005 ; "Isolation, purification and application of an ester hydrolase from yeast strain Trichosporon sp. Proceedings of International Conference on Microbial Diversity: Current Perspectives and potential applications held at University of Delhi south Campus, New Delhi from April 16-18, 2005. 52. Singh, S.K., Bhusari, S., Andrabi, R., Pal, H.C., Mondhe, D.M., Verma, V., Saxena, A.K., Johri, R.K. and Qazi, G.N. 2007 ; "Pre-clinical pharmacodynamic & pharmacokinetic evaluation of natural product as anti-cancer investigational new drug IND ; " Proceedings of International Symposium on Genomic instability and cancer held at SKICC, Srinagar from July22-26, 2007. P19 and luvox.
This group of drugs includes: prozac fluoxetine ; lexapro escitalopram ; zoloft sertraline ; celexa citalopram ; effexor venlafaxine ; paxil paroxetine ; cymbalta duloxetine ; group 2: tricyclic antidepressants tcas.
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Figure 2: Open field behavior after 1 day OF1 ; , 13 days OF2 ; and 20 days OF3 ; of footshock stress. The results are expressed as group means + SEM. A ; Zone definition of the arena. At the start of each trial the rat is placed in the tube. B ; Total distance moved in the arena. C ; Distance moved in the inner zone of the arena see A ; . D ; Time spent in the tube area in on and around the tube, see A ; . The behavior did not change in subsequent trials during control conditions, while after stress behavioral changes were recorded in non-lesioned rats after 20 days and in mPFC lesioned rats already after 13 days. * , p 0.05 and bupropion.
Lantus U-100 insulin glargine ; Lasix furosemide ; Lescol fluvastatin ; Lescol XL fluvastatin sodium ; Leucovorin leucovorin ; Leukeran chlorambucil ; Leukine sargramostim ; Leuprolide leuprolide acetate ; Leustatin cladribine ; Levaquin levofloxacin ; Levemir insulin detmir ; Levobunolol HCL levolbunolol ; Levothroid levothyroxine ; Levoxyl levothyroxine ; Levsin-SL Oral hyoscyamine-sl ; Lexapro escitalopram ; Lexiva fosamprenavir ; Lexxel enalapril maleate-felodipine er ; Librax chlordiazepoxide clidinium ; Librium chlordiazepoxide ; Licocin lincomycin hydrochloride ; LidaMantle lidocaine hci ; LidaMantle HC lidocaine hcl 3%- hydrocortisone acetate .5% ; Lidex fluocinonide ; Lidoderm lidocaine ; Lioresal baclofen ; Lipitor atorvastatin ; Lithobid lithium carbonate ; Locoid hydrocortisone butyrate ; Lodosyn carbidopa ; Lodrane antihistamines, decongestants ; Lodrane 12 hour antihistamines, decongestants ; Lodrane 24 antihistamines, decongestants ; Lodrane D antihistamines, decongestants ; Lodrane XR antihistamines, decongestants ; Lomotil diphenoxylate atropine ; Lonox diphenoxylate atropine ; Lopid gemfibrozil ; Lopressor metoprolol ; Lotemax loteprednol ; Lotensin benazepril ; Lotensin HCT benazepril hct ; Lotrel amlodipine with benazepril ; Lotrisone clotrimazole with betamethasone ; Lotronex alosetron ; Lovenox enoxaparin ; Lozol indapamide ; Lucentis ranibizumab ; Lumigan bimatoprost ; Lupron leuprolide ; Luxiq betamethasone valerate ; Lyrica pregablin ; Lysodren mitotane ; M-M-R II measles, mumps, rebella virus vaccine live ; Macrobid nitrofurantoin ; Macrodantin nitrofurantoin ; Macugen pegaptanib sodium ; Mag-Tab SR magnesium l-lactate dihydrate ; Malarone atovaquone and proguanil hydrochloride ; Malarone Pedatric atovaquone and proguanil hydrochloride ; Malarone Pediatric atovaquone and proguanil hydrochloride.
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Thomas Hammond, MD symptoms generally do not respond to L-Dopa or dopaminergic therapy. Several new medications and strategies for treatment of Parkinson's disease have recently been reported. At the American Academy of Neurology AAN ; 60th Anniversary Meeting in Chicago in April of 2008, a new dopamine agonist dAg ; was presented. The new drug Pardoprunax PX ; was presented by a group from the Netherlands as a poster PO2.028. This drug stimulates dopamine receptors in a fashion similar to Mirapex and Requip. However, it has the novel effect of being a full serotonin agonist stimulating 5-HT1A receptors which may offer mood benefits depression is very common in PD ; . this trial, 103 patients with early PD were given either PX or a placebo for three months.The PX group was significantly better in motor function features less tremor, less slowness, better balance ; . When compared to the placebo group, side effects were mild and similar to the side effects for the older dAg agents. Dr. Paul Greengard, Ph.D. from the Rockefeller University laboratory of molecular and cellular neuroscience is a Nobel Laureate for his work on dopamine in PD. Dr. Greengard recently published work in collaboration with the group from Karolinska Institute in Stockholm in which they showed that serotonin may inhibit dyskinesias in PD patients who have been given L-Dopa for years. These researchers identified a protein called p11 that regulates serotonin signaling in the brain. Some evidence suggests that p11 level may be linked to a person's susceptibility to depression the major antidepressants such as Prozac, Zoloft, Paxil, Celexa, Lexapro and others all act on serotonin ; . P11 also seems to play a role in dyskinesias in PD. They conclude that drugs that target serotonin 1B and p11 will likely help in treating advanced PD. The study presented at the AAN on PX, as discussed above, was performed on early PD patients, however, studies are ongoing in late stage PD with dyskinesias and motor fluctuations. We can look forward to this new agent for PD possibly being useful in both early and late disease with potential antidepressant effects as a bonus. Another new drug for Parkinson's disease with a novel mechanism of action was recently reported in the May 2008 Archive of Neurology. Tesofensine TE ; is a monoamine reuptake inhibitor which blocks uptake of dopamine, noradrenaline and serotonin and also stimulates cholinergic neurons in the brain. Methylphenidate Ritalin ; has some similar effects on dopamine reuptake in the brain and some studies Continued on page 6.
Being an "active patient" by researching therapies in libraries and on the Internet at encyclopedic drug databases, such as the WebMD or onHealth Web sites ; . Meanwhile, our providers and agents seek assurances in more professional ways--mysterious to us, but not to those involved: drug review by medical insurers and buy tofranil.
Mj bipolar nos, add 1200mg lithobid, 5mg abilify, 5mg lexapro, 30mg vyvanse, mg xanax xr, neurontin titrating up to 600mg netsavy006 view member profile wed 18 june 2008 : 57 gmt + 0000 post #10 amateur psychopharmacologist group: members 241 joined: sat 8 september 2007 member no: 332 diagnoses: asperger's + bipolar 1: mixed episode current meds: lexapro 5mg + abilify 15mg + cogentin 2mg my doctor agrees that the fewer meds the better, however zyprexa zydis made me gain 24 pounds.
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Brazilians are very family-oriented. Many hotels let children stay free, although the age limit varies. Babysitters are readily available and most restaurants have high chairs. Lonely Planet's Travel with Children, by Cathy Lanigan, gives a lot of good tips and advice on traveling with kids in the tropics. There's plenty of good spade and sandbucket fun to be had on Rio's beaches, particularly Leblon's posto 12, known as Baixo Bbe for its mini-playground and all the moms and tots around. Other amusement for kids includes the shows and exhibits at the Planetrio p128 ; , the animals of Jardim Zoolgico at Quinta da Boa Vista p156 ; , the impressive ships at Espao Cultural da Marinha p153 ; , and the mechanized displays at the Museu de Folclrico Edson Carnerio p151 ; . You can also hire bikes including big, shaded four-seaters ; and visit the playground near the bike stand at Lagoa Rodrigo de Freitas p128 ; . In addition, children may also enjoy the following sights: Mini-Rio Map p137; 1st fl, Barra Shopping, Av das Amricas, Barra da Tijuca; h10am-10pm ; Small amusement area with bumper cars, boat and plane rides for little ones. Museu Aerospacial Map p137; %2108 8954; www .musal.aer l in Portuguese; Av Marechal Fontenele 2000, Campo dos Afonsos; admission free; h9am-3pm Tue-Fri, 9: 30am-4pm Sat & Sun ; Expositions on Santos Dumont the Brazilian father of aviation ; and the role of Brazil's air force in WWII. Lots of old planes, including replicas of Santos Dumont's planes: the 14 Bis and the Demoiselle.
All generic medications are on the PRx formulary. Please use this quick reference list when you receive a prescription. To receive maximum prescription drug benefits, ask you doctor to prescribe a medication on the formulary. Remember, if a drug from the formulary is prescribed, your co-pay may be less than if a non-formulary drug a drug not on the complete formulary list ; is prescribe for you. To see the complete formulary visit under Services-or call toll free 877-468-5279. You must register and login to access the services. Drugs are listed alphabetically by brand name. KEY: generic medication lowest co-pay ; listed in all lower-case letters. Brand-name Medications middle co-pay ; listed with a leading capital letter * -brand versions of these drugs are nonformulary highest co-pay ; Acots Advair Aldara Alocril Alora Alphagan P Alupent * metapruterenol ; Amaryl Ambien Amoxil * amoxicillin ; Anapros, DS * naproxen sodium, DS ; Ansia * flurbiprofen ; Atrovent * ipatropium bromide ; Augmentin * amox clav ; Avandamet Avandia Avapro Azmacort Bactrin, DS * sulfamethoxazole trimethoprim ; Betagan * levobunolol ; Calan, SR * verapamil, SR ; Capoten * captopril ; Carafate * sucralfate ; Cardizem * diltiazem ; Cardura * doxazosin ; Ceclor, CD * cefaclor, ER ; Ceftin * cefuroxime ; Cefzil Celexa Celestine Cipro Climara estradiol ; Combipatch Corgard * nadolol ; Cosopt Coumadin warfarin ; Crolom * cromolyn ; Cytotec * misoprostal ; Dalmane * flurazepam ; Desyrel * trazodone ; Detrol, LA Diabeta * glyburide ; Diflucan Dilacor XR * diltiazem CR ; Diovan, HCT Dyazide * triamterene HCTZ ; Effexor, XR Estrace * estradiol ; Evista FemHRT Flonase Flovent Fosamax Glucophage * metformin ; Glucophage XR Glucotrol, XL glipizide ; Glucovance Glynase Prestab * glyburide micro ; Halcion * triazolam ; Humalog Humulin Hydrodiuril * hydrochlorothiazide ; Hytrin * terazosin ; Imdur * isosorbide mononitrate ; Imitrex Inderal * propranolol ; Inderal LA Indocin, SR * indomethacin, SR ; Intal Inh. Intal Soln. * cromolyn ; ISMO * isosorbide mononitrate ; Isoptin, SR * verapamil, SR ; Isordil * isosorbide dinitrate ; Keflex * cephalexin ; Lanoxin Lantus Lasix * furosemide ; Levaquin Lexapro Lipitor Lodine * etodolac ; Lopid * gemfibrozil ; Lopressor * metoprolol ; Lortab * hydrocodone APAP ; Lotensin, HCT * benazepril HCTZ ; Lotrel Lozol * indapamide ; Lumigan Maxair Maxzide * triamterene HCTZ ; Miacalcin Micronase * glyburide ; Mirapex Monoket * isosorbide mononitrate ; Motrin * ibuprofen ; Nalfon * fenoprofen ; Naprosyn * naproxen ; Nasacort AQ Niaspan Nitro-Dur Nitrostat * nitroglycerin ; Nizoral * ketoconazole ; Norpramin * desipramine ; Norvasc Ocupress * carteolol ; Ogen * estropipate ; Omnicef Omnipen * ampicillin ; Ortho-Est * estropipate ; Orudis * ketoprofen ; Oruvail * ketoprofen ; Pamelor * nortriptyline ; Paxil CR Persantine * dipyridamole ; Plavix Precose Premarin Prempro, Premphase Prinivil * lisinopril ; Prinzide * lisinopril hctz.
Esprit also has right of first refusal for the sale and marketing of ProQuin XR for the Canadian market. Esprit has agreed to pay us a million license fee, of which million has been paid with an additional million due in July 2006 and the remaining million due in July 2007. Also under the agreement, Esprit will pay us 15 percent to 25 percent escalating royalties based on increasing sales of ProQuin XR. In connection with the license agreement, we also entered into a related supply agreement with Esprit, pursuant to which we will supply commercial quantities of ProQuin XR to Esprit. In November 2005, Esprit launched ProQuin XR in the United States. In 2005, we recognized approximately , 024, 000, or 46% of our total revenue for the year, under our agreements with Esprit. To date, all of our revenues from product sales and royalties have come from Esprit under our supply agreement with Esprit and our exclusive license and marketing agreement with Esprit. If our agreements with Esprit related to ProQuin XR were to be terminated, whether due to a breach of those agreements by us, by Esprit, or otherwise, our business, results of operations and financial condition would be adversely affected. Madaus S.r.l. In November 2005, we entered into a distribution and supply agreement for ProQuin XR in Europe with privately owned specialty pharmaceutical company Madaus S.r.l. Under the terms of the agreement, we granted an exclusive right to Madaus for the commercialization of ProQuin XR in Europe and agreed to supply Madaus with commercial quantities of ProQuin XR tablets in bulk form. Madaus will pay us at a prespecified percent of Madaus' wholesale ex-factory price, net of packaging costs. In January 2006, Madaus paid us a 0, 000 license fee. An advance payment against future product sales of 0, 000 will be due within 30 days of the first European regulatory approval. No revenue was recognized under the agreement in 2005. New River Pharmaceuticals, Inc. In June 2005, we entered into a development and license agreement with New River Pharmaceuticals Inc. to develop through the feasibility phase up to three proprietary New River compounds in combination with the AcuForm technology. Pursuant to the agreement, New River will fund research and development under the agreement, and New River may acquire worldwide rights to use the AcuForm technology in the product candidates for agreed-upon milestone payments and royalties. New River has proposed an initial product candidate for development, and we are collaborating with New River on the work plan for the feasibility program and expect to begin development work on the product in the second quarter of 2006. No revenue was recognized under the agreement in 2005. Boehringer Ingelheim Pharmaceuticals, Inc. In April 2005, we entered into an agreement with Boehringer Ingelheim Pharmaceuticals, Inc. to conduct feasibility studies with an undisclosed pharmaceutical compound and in December 2005, we completed the studies and delivered the agreed feasibility results. All research and development work with the partner's drug was funded by the partner. We are not aware of any additional work that we will be requested to perform on this pharmaceutical compound. For the year ending December 31, 2005, we recognized , 231, 000 or 51% of our total revenue for the year, which approximated the costs under the agreement related to this collaboration. LG Life Sciences, Ltd. In August 2004, we entered into a license and distribution agreement granting LG Life Sciences an exclusive license to the 500mg Glumetza in the Republic of Korea. Upon signing of the agreement, LG paid us a 0, 000 upfront license fee. The agreement also provides for a 0, 000 milestone fee upon approval in Korea and royalties on net sales of the 500mg Glumetza. The upfront license fee will be amortized over a period of eight years, which represents the estimated length of time that we are obligated to provide assistance in development and manufacturing. For the years ended December 31, 2005 and 2004, we recognized , 000 and , 000 or 2% and 15%, respectively, of our total revenue for the years related to this collaboration. Biovail Laboratories International. In December 2005, we and Biovail entered into an Amended and Restated License Agreement relating to Glumetza. The Amended and Restated License Agreement supersedes our April 27, 2004 Amended License and Development Agreement with Biovail. Pursuant to the Amended and Restated License Agreement: i ; we granted Biovail an exclusive license in Canada to manufacture and market the 500mg formulation of Glumetza, and a non-exclusive license to.
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